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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

Fig. 1

Local anesthetics prilocaine, lidocaine, procaine, and ropivacaine impaired cell survival through inhibition of ZDHHC15 expression. Histogram showing the viability of GSCs cultured in CSC medium with or without local anesthetics (procaine, benzocaine, procaine, dibucaine, tetracaine, oxadiazine, lidocaine, propoxycaine, levobupivacaine, bupivacaine, and ropivacaine) for 24 h (left) or 48 h (right) at different concentrations (5, 10, and 20 μM, respectively). Local anesthetics, such as prilocaine, lidocaine, procaine, and ropivacaine, killed GSCs in a concentration- and time-dependent manner. a ART-PCR analysis of mRNA levels of 24 known pats in GSC treated with prilocaine, lidocaine, procaine, and ropivacaine (20 μm each). β-Actin was used as a loading control. b RT-PCR analysis of ZDHHC15 mRNA levels in GSCs treated with different concentrations (5, 10, and 20 μM) of prilocaine, lidocaine, procaine, and ropivacaine. β-Actin was used as a loading control

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