Fig. 4

Improvement of light-evoked electroretinogram (ERG) signals by hPBMC injection. Each eye was stimulated simultaneously for 2 ms with ultraviolet light (365 nm) at 1.6 log(Cd s/m²) and green light (505 nm) at 1.3 log(Cd s/m²). Light-evoked ERG responses as observed in wild type C57 mice (n = 6) (middle panels) were absent or markedly smaller in untreated (n = 10) and control group rd1 mice (n = 10) (left panels). Response was also largely absent in treatment group mice at 1 month (n = 30) post-injection but both a and b waves were relatively large at 3 months (n = 20) post-injection (right panel)