Fig. 5

Transplantation of anti-miR-34a-MSCs improves cardiac function following infarction in diabetes rats. To establish the DM animal model, the rats were fed with high-fat diet for 8 weeks, intraperitoneally injected with streptozotocin (STZ) (25 mg/kg/day) and following high-fat diet for 4 weeks. To induce an acute MI model, the left anterior descending coronary artery (LAD) was ligated. a Blood glucose were determined in the DM group or the normal group. b ECG was taken before or after the LAD ligated. c–e Representative echocardiography images were taken at the baseline and 1 week and 3 weeks after MI. f–h Representative images of Masson’s and TTC staining were taken to detect the infarction area. Each column represents mean ± SD from three independent experiments. *P < 0.05