Fig. 1

ECFCs compared to other endothelial cells harbored a distinct expression profile implicated in abnormal vascular development. a An unsupervised principal component analysis was performed with regulated endothelial-related genes on dataset GSE55695 comparing ECFC_PB (ECFCs in peripheral blood) to distinct groups of endothelial cells (EC_ADIPO, EC_skin and HUVECs, p value of group discrimination was calculated on the first principal axis). b Expression heatmap of endothelial-related genes performed on transcriptome samples from dataset GSE55695 (unsupervised classification was realized with Euclidean distances with complete method). c Functional enrichment network performed with regulated endothelial-related genes in dataset GSE55695 after enrichment on Mouse Phenotype database: circles represent genes; octagons represent enriched function; blue edges represent link(s) between functions and enriched genes; fill color with scale color ranging from blue to red is relative to negative logarithm 10 of the p values obtained during the enrichment