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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Induced neural stem cell grafts exert neuroprotection through an interaction between Crry and Akt in a mouse model of closed head injury

Fig. 2

Akt inhibition reduced Crry expression in iNSCs pre-treated with CHI mouse serum. a Representative immunoblots depicting the levels of C3d, C9, Crry, active Caspase-3, p-AKT, and AKT in iNSCs among the PBS (iNSCs receiving PBS pre-treatment), CHI (iNSCs receiving CHI mouse serum pre-treatment), and CHI+LY294002 (iNSCs receiving CHI mouse serum and LY294002 pre-treatment) groups following treatment with CHI mouse serum for 45 min. bh Histograms showing the relative levels of C3d (b), C9 (c), Crry (d), active Caspase-3 (e), p-AKT (f), AKT (g), and p-AKT/AKT (h) in iNSCs among the three groups after CHI mouse serum treatment (n = 6/group; one-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001)

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