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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Induced neural stem cell grafts exert neuroprotection through an interaction between Crry and Akt in a mouse model of closed head injury

Fig. 8

Intracerebral transplantation of iNSCs receiving CR2-Crry pre-treatment influenced Crry expression, Akt, and complement activation in the brains of CHI mice. a Representative immunoblots depicting the levels of C3d, C9, Crry, active Caspase-3, p-AKT, and AKT in the brains of mice among the PBS (CHI mice receiving PBS), iNSC (CHI mice receiving iNSCs pre-treated with PBS), and iNSC (CR2-Crry) (CHI mice receiving iNSCs pre-treated with CR2-Crry) groups on day 14 post-CHI. bh Histograms showing the relative levels of C3d (b), C9 (c), Crry (d), active Caspase-3 (e), p-AKT (f), AKT (g), and p-AKT/AKT (h) in the brains of mice among the three groups at 14 days after CHI (n = 6/group; one-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001)

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