Skip to main content

Table 1 Description of cytokines and growth factors produced in vivo that may be required for fetal liver HSC culture in the presence of hepatic cells. STM septum transversum mesenchyme, HSPC hematopoietic stem and progenitor cells

From: Fetal liver hematopoiesis: from development to delivery

Cytokine/growth factor Cell type promoted Cell of origin in vivo In vitro concentration ranges
SCF HSPC Endothelial cells 1–100 ng/ml [22, 23, 25, 29, 48]
TPO HSPC, Megakaryocytes Endothelial/hepatocytes 1–100 ng/ml [23, 48]
IGF2 HSPC Hepatocytes 20 ng/ml [22, 23, 55, 56]
ANGPTL2,3 HSPC Hepatocytes 100 ng/ml [22, 23]
BMP4 Hepatocyte Cardiac mesoderm/STM 20 ng/ml [41, 57]
FGF2 Hepatocyte Cardiac mesoderm/STM 10 ng/ml [41, 57]
HGF Hepatocyte Mesenchyme 10–20 ng/ml [41, 42]
Oncostatin M Hepatocyte Macrophages, Stellate cells 10–20 ng/ml [41, 43]