Fig. 4

Enhanced in vivo anti-inflammatory and migration potential of Ad-MSCs co-expressing CXCR4 and IL10. a Schematic diagram of a local inflammation mouse model based on the injection of LPS in the right pad of mice. b Characterization of the LPS-induced inflammation in mouse pads. Pad thickness was determined with an electronic caliber at different time points after LPS injection. Data are represented in comparison with the thickness of the contralateral pad injected with PBS. The statistical analysis was made with respect to the 24 h post-LPS group. c Schematic diagram used to investigate the anti-inflammatory effects of Ad-MSCs in LPS-induced inflamed pads. d Evolution of local inflammation of LPS-treated pads at different time points after Ad-MSC infusion. Data are represented as the percentage of the inflammation observed in LPS-treated animals infused with WT-MSCs. Data represents the mean ± SEM of at least n = 15 mice/group with Tukey’s multiple comparison test applied. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001