Table 3 The effects of the functional regulation and mechanisms of different genes and compounds on the function of the MSCs through changes in the mitochondrial energy metabolism pathway
MSC type | Gene/compound | Energy metabolism pathway | Functional regulation and mechanism | Reference |
|---|---|---|---|---|
BMSCs | Dimethyloxalylglycine | Increase glycolysis and inhibit OXPHOS | Inhibit the osteogenic differentiation ability of the BMSCs | Shum LC et al., Stem Cells Dev, 2016 [25] |
C3H10T1/2 mesenchymal stem cells | Antimycin A | Inhibit OXPHOS | Inhibit the osteogenic differentiation ability of the C3H10T1/2 mesenchymal stem cells | Shares BH et al., J Biol Chem, 2018 [66] |
BMSCs | TFAM | Inhibit OXPHOS | Inhibit the adipogenic differentiation ability of the BMSCs | Zhang Y et al., PLoS One, 2013 [24] |
AD-MSCs | Mangiferin | Increase OXPHOS | Induce the differentiation of the AD-MSCs into brown adipocyte phenotype and improve obesity | Rahman MS et al., Metabolism, 2020 [67] |
C-MSCs | Rab27b | Increase OXPHOS and inhibit glycolysis | Maintain fatty acid oxidative metabolism of C-MSCs | Jin Y et al., Front Cell Dev Biol, 2020 [68] |
BMSCs | Canagliflozin | Inhibit OXPHOS | Inhibit the proliferation and migration of the BMSCs, which may lead to the decrease in tissue repair abilities of BMSCs | Wanet A et al., Int J Biochem Cell Biol, 2014 [47] |