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Table 3 The effects of the functional regulation and mechanisms of different genes and compounds on the function of the MSCs through changes in the mitochondrial energy metabolism pathway

From: The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells

MSC type Gene/compound Energy metabolism pathway Functional regulation and mechanism Reference
BMSCs Dimethyloxalylglycine Increase glycolysis and inhibit OXPHOS Inhibit the osteogenic differentiation ability of the BMSCs Shum LC et al., Stem Cells Dev, 2016 [25]
C3H10T1/2 mesenchymal stem cells Antimycin A Inhibit OXPHOS Inhibit the osteogenic differentiation ability of the C3H10T1/2 mesenchymal stem cells Shares BH et al., J Biol Chem, 2018 [66]
BMSCs TFAM Inhibit OXPHOS Inhibit the adipogenic differentiation ability of the BMSCs Zhang Y et al., PLoS One, 2013 [24]
AD-MSCs Mangiferin Increase OXPHOS Induce the differentiation of the AD-MSCs into brown adipocyte phenotype and improve obesity Rahman MS et al., Metabolism, 2020 [67]
C-MSCs Rab27b Increase OXPHOS and inhibit glycolysis Maintain fatty acid oxidative metabolism of C-MSCs Jin Y et al., Front Cell Dev Biol, 2020 [68]
BMSCs Canagliflozin Inhibit OXPHOS Inhibit the proliferation and migration of the BMSCs, which may lead to the decrease in tissue repair abilities of BMSCs Wanet A et al., Int J Biochem Cell Biol, 2014 [47]