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Table 4 The effects of the functional regulation and mechanisms of different enzymes and compounds on the MSCs through changes in mitochondrial membrane potential

From: The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells

Enzymes/compounds MSC type Change in the membrane potential Functional regulation and mechanism References
CPT1A PD-MSCs Reduce Overexpression in senescent PD-MSCs leads to cell senescence Seok J et al., Stem Cell Res Ther, 2020 [73]
Decitabine BMSCs Reduce Apoptosis of BMSCs Wang L et al., Eur J Pharmacol, 2019 [27]
Melatonin BMSCs Increase Protects the BMSCs from replicative senescence during proliferation Lee JH et al., Ageing Cell, 2020 [74]
Pioglitazone NP-MSCs Increase Inhibits oxidative stress and mitochondrial apoptosis, and protects the proliferation of NP-MSCs Hu Y et al., Oxid Med Cell Longev, 2019 [75]