Table 4 The effects of the functional regulation and mechanisms of different enzymes and compounds on the MSCs through changes in mitochondrial membrane potential
Enzymes/compounds | MSC type | Change in the membrane potential | Functional regulation and mechanism | References |
|---|---|---|---|---|
CPT1A | PD-MSCs | Reduce | Overexpression in senescent PD-MSCs leads to cell senescence | Seok J et al., Stem Cell Res Ther, 2020 [73] |
Decitabine | BMSCs | Reduce | Apoptosis of BMSCs | Wang L et al., Eur J Pharmacol, 2019 [27] |
Melatonin | BMSCs | Increase | Protects the BMSCs from replicative senescence during proliferation | Lee JH et al., Ageing Cell, 2020 [74] |
Pioglitazone | NP-MSCs | Increase | Inhibits oxidative stress and mitochondrial apoptosis, and protects the proliferation of NP-MSCs | Hu Y et al., Oxid Med Cell Longev, 2019 [75] |