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Table 5 The effects of functional regulation and mechanisms of compounds on MSCs through changes in ROS levels and oxidative stress

From: The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells

Therapeutic method/compound MSC type Functional regulation and mechanism References
Mg Rat bone marrow mesenchymal stem cells Reduce the risk of apoptosis induced by ultraviolet radiation Chen Y et al., J Biomed Mater Res A, 2019 [87]
17β-estradiol UCB-MSCs Increase the nuclear translocation of Nrf2 to protect UCB-MSCs from high glucose-induced mitochondrial ROS production, and thereby protect the cells from autophagic cell death Oh JY et al., Free Radic Biol Med, 2019 [88]
Pioglitazone NP-MSCs Decrease the compression-induced overproduction of ROS, protect cell viability and cell proliferation of NP-MSCs, and alleviate the toxic effects caused by compression Hu Y et al., Oxid Med Cell Longev, 2019 [75]
NAC and l-ascorbic acid 2-phosphate AD-MSCs Promote the growth of human AD-MSCs and suppress the oxidative stress-induced cell death by enhancing mitochondrial integrity and function Li CJ et al., Oxid Med Cell Longev, 2017 [89]