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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Silencing Smad7 potentiates BMP2-induced chondrogenic differentiation and inhibits endochondral ossification in human synovial-derived mesenchymal stromal cells

Fig. 5

Silencing Smad7 enhances the BMP2 induced subcutaneous ectopic cartilage formation (a). Before and after thermal-induced gelation of PPCNg alone, respectively. b Illustrative diagram showing that hSMSCs treated as experimental design seeded on the scaffolds was implanted into the subcutaneous space of the nude mice and harvested for analysis after 4 weeks. c Macrographic images of ectopic masses. The micro-CT scanning to determine the surface and the volume of mass. d The retrieved masses were subjected to microCT analysis: Quantification results of the relative values of BV/TV were analyzed. These data are shown as mean ± SD repeat triplicate. *P < 0.05, **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512