Fig. 6

FGF21- and GLP1-modified MSCs could improve glucolipid metabolism in vitro. a Quantitative real-time PCR detected the effect of FGF21- and/or GLP1-modified MSCs on the expression of srebp1c mRNA in HepG2 cells. Blank vector-modified MSCs were used as a negative control, and liraglutide was used as a positive control. The β-actin gene was used as the reference gene, **P < 0.01, ***P < 0.001, compared to the MSC vector. b Quantitative real-time PCR detected the influence of FGF21- and/or GLP1-modified MSCs on the expression of insulin mRNA in INS-1 cells. Blank vector-modified MSCs were used as a negative control, and liraglutide was used as a positive control. The GAPDH gene was used as the reference gene, **P < 0.01, ***P < 0.001, compared to the MSC vector. c Insulin secretion in INS-1 cells incubated in conditioned medium with different modified MSCs. Blank group was KRBH medium without any added reagent. Blank vector-modified MSCs and liraglutide acted as the negative and positive controls, respectively, *P < 0.05, **P < 0.01, compared to the MSC vector