Fig. 5
From: mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
mTOR inhibitor INK128 inhibits accumulation of MDSCs. a INK128 inhibited the proliferation of MDSCs in vitro. b INK128 decreased the accumulation of glucose-induced MDSCs in vitro. c The construction process of DM and DM + INK128 models. d–f INK128 inhibited the accumulation of MDSCs in marrow, PBMC, and spleen of DM at day 3 after injury. g–i INK128 inhibited the accumulation of MDSCs in marrow, PBMC, and spleen of DM at day 7 after injury. j, k Immunofluorescence staining showed that INK128 decreased the accumulation of Gr-1+ cells in skin tissue around the wound of DM at day 3 and day 7 after injury. MDSCs, myeloid-derived suppressor cells; PBMC, peripheral blood mononuclear cell; DM, diabetic mice