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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: mTOR inhibitor INK128 promotes wound healing by regulating MDSCs

Fig. 5

mTOR inhibitor INK128 inhibits accumulation of MDSCs. a INK128 inhibited the proliferation of MDSCs in vitro. b INK128 decreased the accumulation of glucose-induced MDSCs in vitro. c The construction process of DM and DM + INK128 models. df INK128 inhibited the accumulation of MDSCs in marrow, PBMC, and spleen of DM at day 3 after injury. gi INK128 inhibited the accumulation of MDSCs in marrow, PBMC, and spleen of DM at day 7 after injury. j, k Immunofluorescence staining showed that INK128 decreased the accumulation of Gr-1+ cells in skin tissue around the wound of DM at day 3 and day 7 after injury. MDSCs, myeloid-derived suppressor cells; PBMC, peripheral blood mononuclear cell; DM, diabetic mice

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