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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: mTOR inhibitor INK128 promotes wound healing by regulating MDSCs

Fig. 8

INK128 inhibits the differentiation of M-MDSCs into M1 macrophages in DM. a, b The MDSCs differentiated into M-MDSCs in bone marrow and spleen of DM. c, d INK128 decreased the MDSCs to differentiate into M-MDSCs in bone marrow and spleen of DM. e, f INK128 inhibited the differentiation of glucose-induced MDSCs into M-MDSCs in vitro. g The construction process in differentiation of MDSCs/M-MDSCs into macrophage models. h, i INK128 inhibited mainly the differentiation of glucose-induced M-MDSCs into M1 macrophage. * P < 0.05; **P < 0.01. M-MDSCs, M-myeloid-derived suppressor cells; CON, control mice; DM, diabetic mice; DM + INK128, the diabetic mice treated with INK128

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