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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Myogenic progenitor cell transplantation for muscle regeneration following hindlimb ischemia and reperfusion

Fig. 4

Engraftment and persistence of MPC following ischemia. a Representative bioluminescence images of mice, which had their right hindlimb either subjected to 2h WIT (D2, n = 8) or not (D1, n = 7) followed by injection of 1 mio luciferase reporter expressing MPC into the tibialis anterior muscle. Depicted images represent 1 of 30 images taken on POD 20, 40, 60, and 75 show bioluminescence signals as heatmap (red = high, blue = low signal). Red circles depict area for quantification of signals. b Luciferase signal quantification (area under the curve; AUC) of mice receiving intramuscular injection of luciferase MPC, following 2h warm ischemia (WIT2H, D2) or no ischemia (CTR, D1). Luciferase signals quantified by background corrected area under the curve of 30 min (1 measurement per minute) analysis on day 20, 40, 60, and 75 post cell implantation (POD). Data presented as Tukey’s boxplots (mean shown as “+”). MPC, myogenic progenitor cell; POD, postoperative day; WIT, warm ischemic time

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