Table 2 Effects and mechanisms of huMSCs on POF
From: Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunities
Infertility model | Treatment | Main effect of huMSCs on POF | Species | References |
|---|---|---|---|---|
CTX-induced POF | Intravenous injection | Stem cell homing (+), number of healthy follicles at different stages (+), granulosa cell apoptosis (−) | Mice | [12] |
Super-ovulation-induced POF | Intravenous injection (IV) and situ ovarian micro injection (MI) | Restore ovarian function (+, IV > MI) Homing in the medulla, cortex, and epithelium of injured ovaries | Mice | |
Aging female rats | IV | HGF, VEGF, and IGF-1 (+) | Rats | [98] |
ZP3-induced POF | IV | E2, P, and IL-4 (+); FSH, IFN-γ, and IL-2(−); Th1/Th2 (−); improve endometrial conditions (+); number of healthy follicles (+); number of atretic follicles (−) | Mice | [99] |
CTX-induced POF | IV | Folliculogenesis (+), NGF and pregnancy rate (+), NGF and TrkA (+), FSHR and caspase-3 (−) | Rats | [100] |
Paclitaxel-induced POF |  | FSH (−); E2 (+); antral follicle (+); CK 8/18, TGF-ß, and PCNA (+); CASP-3(−) | Rats | [101] |
Busulfan and CTX-induced POF | HuMSC-MVs (IV) | Homing (+); ovarian weight (+); ovarian angiogenesis (+); recover the disturbed estrous cycle (+); total AKT, p-AKT, VEGF, IGF, and angiogenin (+) | Mice | [102] |
Cisplatin-induced POF | HuMSC-EXOs | Granulosa cell apoptosis (−), DNA repair proteins (+) | GCs | [103] |
Busulfan and CTX-induced POF | Co-culture of UC-MSCs and GCs (i.p.) | HO-1 expressed in UC-MSCs can restore the ovarian function JNK/Bcl-2-associated cytokines (+) | Mice | [104] |
CTX-induced POF | Collagen/UC-MSC transplantation | Ovarian volume (+), number of antral follicles (+), GC proliferation (+), CD31 (+), phosphorylation of FOXO3a and FOXO1 (+) | Mice |