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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p

Fig. 2

hsa_circ_0006859 suppresses osteoblastic differentiation. a Relative hsa_circ_0006859 expression in hBMSCs during osteogenic differentiation. b Relative hsa_circ_0006859 expression in hBMSCs after transfection with OE-circ or si-circ. c Relative OCN mRNA expression in hBMSC after transfection with OE-circ or si-circ. d Relative ALP mRNA expression in hBMSCs after transfection with OE-circ or si-circ. e Western blot analysis of OCN and ALP expression in hBMSCs after transfection with OE-circ or si-circ. f ALP activity in hBMSCs after transfection with OE-circ or si-circ. g Alizarin red staining was used to detect the mineralization ability of hBMSCs after transfection with OE-circ or si-circ. ***P < 0.0001

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