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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p

Fig. 4

hsa_circ_0006859 directly binds to miR-431-5p. a Bioinformatics analysis of the predicted binding sites between hsa_circ_0006859 and miR-431-5p. b Luciferase activity of hsa_circ_0006859 circ-#1-Wt and circ-#1-Mut upon miR-431-5p overexpression. c Luciferase activity of hsa_circ_0006859 circ-#2-Wt and circ-#2-Mut upon miR-431-5p overexpression. d Relative miR-431-5p expression in hBMSC after transfection with OE-circ or si-circ. e RNA pull-down assay of the interaction between hsa_circ_0006859 and miR-431-5p

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