Fig. 6
From: hiPSC-derived NSCs effectively promote the functional recovery of acute spinal cord injury in mice
The recovery of locomotor function following stem cell transplantation after SCI. The locomotor function of PBS- or stem cell-treated mice was assessed using the BMS test: BMS score (a), subscore (b), coordination (c), trunk (d), and the stepping score of right side (e) and left side (f). All animals in the NSC group showed significantly higher performance in the open-field BMS test than MSC-treated animals and PBS controls (a). Significantly higher subscores were recorded for the NSC group than the other treatment groups. Additionally, the MSC-transplanted animals did not show better performance than controls (b). Regarding coordination (c), for which body weight-supported stepping is essential, a stable but insignificant trend of higher performance was observed in the NSC group. The trunk function in the NSC group recovered earlier and to a greater extent than the MSC and control groups (d). A stable but insignificant trend of higher performance on stepping function was observed in the NSC group after the grafting of stem cells (e, f). g–i, Mouse limb function at dpo 1; g′–i′, mouse limb function at dpo 28. *p < 0.05 compared with the control group; #p < 0.05 compared with the MSC group