Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients with coronary artery disease

Fig. 4

GPR4 gene transfer restored acid-mediated angiogenesis in EPCs derived from CAD patients. a, b Representative photographs and quantitative analyses of tube formation (a scale bar = 40 μm) and migration (b scale bar = 20 μm) of EPCs incubated in different pH environments after 6 h (n = 6). c Representative photographs and quantitative analyses of blood flow in hind limb ischemia in nude mice after injection of EPCs. n = 6 per group. A paired t test was performed to determine the statistically significant differences among groups. d HE, IHC-CD31, and IF-CD31-stained sections of ischemic hind limbs. Scale bar = 20 μm. The data are presented as the mean ± SD. ***P < 0.001

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512