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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients with coronary artery disease

Fig. 5

Changes in GPR4 levels influence acid-mediated angiogenesis in EPCs. a, b Representative photographs and quantitative analyses of p-STAT3, STAT3, and VEGFA protein expression in EPCs derived from non-CAD and CAD individuals in different pH environments (n = 6). cf Representative photographs and quantitative analyses of p-STAT3, STAT3, and VEGFA protein expression in EPCs derived from non-CAD and CAD individuals in different pH environments. EPCs were transfected with siRNA-GPR4 and negative control siRNA (NC) (n = 6) or plasmids expressing GPR4, negative control plasmids (NC), and NSC74589 (n = 6). The data are presented as the mean ± SD. *P < 0.05, ***P < 0.001

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