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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: METTL3-mediated m6A modification regulates cell cycle progression of dental pulp stem cells

Fig. 2

m6A modification features and related gene expressions in DPSCs. Expression profiles of m6A peak fraction and distribution in DPSCs transcript segments were analyzed by m6A RIP-seq. a Specific sequence motif of m6A peaks identified by the HOMER database. b Distribution of m6A peaks in 3′ UTR, CDS region, and 5′ UTR. c Pie chart analysis of m6A peak fraction in transcript segments. d The distribution of transcription factor-binding loci relative to transcription start sites (TSS). The m6A-related gene expressions in immature and mature dental pulp tissues and DPSCs. e mRNA expressions of METTL3, METTL14, WTAP and FTO, and ALKBH5 in immature dental pulp tissues and mature ones evaluated by PCR. f In the GEO databases, relative gene expressions of METTL3, METTL14, WTAP and FTO, ALKBH5, YTHDF1, YTHDF2, and YTHDF3 in immature DPSCs and immature ones were analyzed by GEO2r. Quantitative data are represented as mean ± SD, Student’s t test. *p < 0.05. **p < 0.01. ***p < 0.001

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