Fig. 2

NSC tropism kinetics. a Photographs of ovarian tumor nodules (left panel, outlined in red) and centrifuged lavage cell pellets (center panel) after IP administration of 1 × 10⁷ DiR-labeled NSC.AuNRs, demonstrating the localization of black NSCs in the lavage fluid at 1 h and in tumors at 24 h. The lavage cell pellets were also imaged with fluorescence microscopy (right panel) to visualize the number of DiR-labeled NSC.AuNRs (magenta) at each time point. Anti-CD45 antibodies were used to visualize macrophages (blue). b ICP-MS quantification of NSC-delivered AuNRs within ovarian metastases (solid lines) and peritoneal lavage fluid (dashed lines) over a 72-h period following IP NSC administration into tumor-bearing nude mice. Each point represents the mean ± standard deviation for n = 3 mice/time point