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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling

Fig. 2

Osthole significantly increased the bone mass of aged mice. Twelve-month-old C57BL/6J mice were treated with osthole (5 mg/kg/day) or vehicle (corn oil) by intraperitoneal injection once a day for 4 weeks. Then, mice were sacrificed, and the lumbar vertebrae were harvested for evaluation. a The μCT 3D image analysis of L4 samples showed that osthole significantly increased bone mass in aged mice. b, c An apparent increase in bone volume (BV) and bone mineral density (BMD) was observed in aged mice after treatment with osthole by the quantitative analysis (n = 6). d, e Osthole was found to significantly increase Tb.N (P < 0.05) and decreased Tb.Sp (P < 0.05). *P < 0.05, **P < 0.01, unpaired Student’s t test (osthole vs. vehicle)

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