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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model

Fig. 2

RNA expression analyses of pluripotency (a, c) and SMC-associated (b, d) genes. a Expression of pluripotency-associated markers NANOG, OCT4, and SOX2 was lower in VSMCs derived from NR (green) and R WT (red) iPSCs than in undifferentiated iPSCs. b SMC-associated markers TAGLN, CNN1, and CALD1 were upregulated in VSMCs derived from NR (green) and R WT (red) iPSCs compared with undifferentiated iPSCs. c NR KO (orange) and R KO (blue) lines showed significant downregulation of pluripotency genes NANOG, OCT4, and SOX2. d SMC-associated markers TAGLN, CNN1, and CALD1 were upregulated in VSMCs derived from NR (green) and R WT (red) iPSCs compared with undifferentiated iPSCs

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