TY - JOUR AU - Yu, Ting AU - Chu, Si AU - Liu, Xingxing AU - Li, Junyi AU - Chen, Qianyun AU - Xu, Meng AU - Wu, Hui AU - Li, Mingyue AU - Dong, Yalan AU - Zhu, Feng AU - Zhou, Haifeng AU - Hu, Desheng AU - Fan, Heng PY - 2021 DA - 2021/03/15 TI - Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance JO - Stem Cell Research & Therapy SP - 181 VL - 12 IS - 1 AB - The bone marrow mesenchymal stem cell (BMSCs)-derived extracellular vesicles (EVs) open up a new avenue for ulcerative colitis (UC) treatment recently, but they are not selectively enriched in targeted tissues. EphB2, a cell-to-cell signaling receptor, is identified as a regulator for inflammatory response, immune homeostasis and cell migration. In this study, we investigated the therapeutic potential and underlying mechanism for EphB2 over-expressing BMSCs derived EVs (EphB2-EVs) in the treatment of UC. SN - 1757-6512 UR - https://doi.org/10.1186/s13287-021-02232-w DO - 10.1186/s13287-021-02232-w ID - Yu2021 ER -