Fig. 4

EphB2-EVs suppress the production of inflammatory mediators and alleviate DSS-induced oxidative stress in colitis rats. a Protein levels of TNF-α, IFN-γ, IL-1β, and IL-2 in colon tissues homogenates from indicated treatment groups by ELISA. b Western blotting analysis of NF-κBp65 and p-NF-κBp65. β-Actin was used as a loading control. c Expression levels of MPO, MDA, GSH, and SOD in colon tissues from indicated treatment groups. ^##P < 0.01 vs. normal group, **P < 0.01 vs. DSS group, ^△△P < 0.01 vs. EVs group