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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Extracellular vesicles derived from EphB2-overexpressing bone marrow mesenchymal stem cells ameliorate DSS-induced colitis by modulating immune balance

Fig. 6

EphB2-EVs regulate the balance of Th17 and Treg cells. The representative FACS plots (a) and the percentages (b) of CD4+ IL-17+ Th17 cells in spleen were analyzed by flow cytometry. c qRT-PCR analysis of transcription factors ROR-γt mRNA expression in colons. The expression level of the mRNA was normalized to β-actin. ELISA analysis of IL-17A (d) and IL-6 (e) levels in colons. The representative FACS plots (f) and the percentages (g) of CD4+ Foxp3+ Treg cells in spleen were analyzed by flow cytometry. h qRT-PCR analysis of transcription factors Foxp3 mRNA expression in colons. The expression level of the mRNA was normalized to β-actin. ELISA analysis of IL-10 (i) and TGF-β1 (j) levels in colons. ##P < 0.01 vs. normal group, **P < 0.01 vs. DSS group, P < 0.01 vs. EVs group

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