TY - JOUR AU - Zhang, Liqiang AU - Zhao, Jiangdong AU - Dong, Jiayi AU - Liu, Yuting AU - Xuan, Kun AU - Liu, Wenjia PY - 2021 DA - 2021/04/06 TI - GSK3β rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs JO - Stem Cell Research & Therapy SP - 225 VL - 12 IS - 1 AB - Premature exfoliation of the deciduous teeth is a common manifestation in childhood patients with hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations. Dysplasia of the cementum, dentin, and alveolar bone has been proposed to be the main reasons for the exfoliation of teeth, while the extraordinarily complex intracellular mechanisms remain elusive. Dental pulp stem cells (DPSCs) have been demonstrated to successfully regenerate functional pulp-dentin-like tissue. Dental pulp cells derived from HPP patients impaired mineralization; however, insight into the deeper mechanism is still unclear. SN - 1757-6512 UR - https://doi.org/10.1186/s13287-021-02235-7 DO - 10.1186/s13287-021-02235-7 ID - Zhang2021 ER -