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Table 2 Safety evaluation by blood tests and blood chemistry examinations at 1, 2 and 4 weeks and urinalysis at 2 and 4 weeks after the transplantation of hypoxia-preconditioned dental pulp stem cells (hpDPSCs)

From: Characterization of stable hypoxia-preconditioned dental pulp stem cells compared with mobilized dental pulp stem cells for application for pulp regenerative therapy

Blood tests
Individual number RBC (106/μL) WBC (103/μL) Platelet count (103/μL) Hematocrit (%)         
pre 7 14 28 pre 7 14 28 pre 7 14 28 pre 7 14 28         
control 6.83 6.66 6.28 6.73 10.61 10.41 10.79 15.77 213 200 183 233 45.2 44.2 42.1 44.0         
1 6.38 6.54 6.16 5.86 9.13 10.04 9.91 9.37 230 223 260 235 41.9 42.8 40.6 38.8         
2 6.62 6.83 6.88 6.20 10.40 9.75 11.26 10.00 296 302 290 264 42.7 44.0 44.2 40.1         
3 7.12 6.73 6.94 7.51 8.06 8.49 8.72 8.50 258 252 266 269 46.2 44.2 45.3 48.5         
average 6.71 6.70 6.66 6.52 9.20 9.43 9.96 9.29 261.33 259.00 272.00 256.00 43.60 43.67 43.37 42.47         
S.D. 0.31 0.12 0.35 0.71 0.96 0.67 1.04 0.61 27.05 32.63 12.96 14.99 1.87 0.62 2.01 4.30         
Normal range 5.10-7.47 6.49-16.61 229-401 33.95-47.67         
Blood Chemistry examination
Individual number AST (IU/L) ALT (IU/L) Albumin (g/dL) Globuline (g/dL) Total choresterol (mg/dL) Glucose (mg/dL)
pre 7 14 28 pre 7 14 28 pre 7 14 28 pre 7 14 28 pre 7 14 28 pre 7 14 28
control 25 27 25 24 41 40 41 35 3.2 3.1 3.1 2.9 2.2 2.1 2.0 2.3 178 182 170 201 94 94 98 93
1 26 23 23 31 55 56 54 91 3.0 2.9 2.9 2.8 2.1 2.5 2.2 2.1 139 157 151 139 94 98 82 88
2 22 20 22 21 45 48 47 44 3.3 3.3 3.4 3.2 2.2 2.3 2.1 2.0 137 150 142 124 94 102 102 98
3 44 27 28 27 42 45 46 48 3.4 3.3 3.3 3.3 2.1 2.1 2.0 2.2 155 149 140 143 87 98 94 95
average 30.7 23.3 24.3 26.3 47.3 49.7 49.0 61.0 3.2 3.2 3.2 3.1 2.1 2.3 2.1 2.1 143.7 152.0 144.3 135.3 91.7 99.3 92.7 93.7
S.D. 9.57 2.87 2.62 4.11 5.56 4.64 3.56 21.28 0.17 0.19 0.22 0.22 0.05 0.16 0.08 0.08 8.06 3.56 4.78 8.18 3.30 1.89 8.22 4.19
Normal range 19-39 20.8-58.8 2.67-3.43 1.8-3.08 101.2-187.6 85.6-110.4
Urinalysis
Individual number Color pH Ketone Bil Oc.Bld Urobil       
pre 13 27 pre 13 27 pre 13 27 pre 13 27 pre 13 27 pre 13 27       
control 0.0 0.0 0.0 6.5 6.0 6.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0       
1 0.0 0.0 0.0 8.5 7.5 7.5 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0       
2 0.0 0.0 0.0 7.0 7.0 7.0 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0       
3 0.0 0.0 0.0 8.0 8.0 6.5 0.0 0.0 0.0 1.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.0       
average 0.0 0.0 0.0 7.8 7.5 7.0 0.0 0.0 0.0 1.0 0.3 0.7 0.0 0.0 1.3 0.0 0.0 0.3       
S.D. 0.0 0.0 0.0 0.6 0.4 0.4 0.0 0.0 0.0 0.0 0.5 0.5 0.0 0.0 1.9 0.0 0.0 0.5       
Normal range 0.0 5.5-8.5 0-1 0-2 0-3 0-1       
Urinalysis
Individual number U.Vol S.Grav Protein(mg/dL) Glucose (mg/dL) Na (mEq/L) K (mEq/L) Cl (mEq/L)    
pre 13 27 pre 13 27 pre 13 27 pre 13 27 pre 13 27 pre 13 27 pre 7 14    
control 140 240 98 1.047 1.030 1.050 13.4 7.6 24.2 8.0 8.0 9.0 55 37 48 195.6 140.1 248.8 117 54 113    
1 60 60 115 1.072 1.046 1.050 48.7 41.3 72.4 10.0 7.0 11.0 49 177 72 366.1 243.1 270.9 260 116 151    
2 100 140 135 1.060 1.037 1.050 12.4 17.1 15.2 10.0 14.0 10.0 86 48 76 285.7 185.5 259.6 171 80 126    
3 170 180 127 1.048 1.047 1.056 11.0 13.0 34.9 6.0 6.0 12.0 39 42 54 216.9 224.7 280.8 123 108 134    
average 110.0 126.7 125.7 1.0600 1.0433 1.0520 24.0 23.8 40.8 8.7 9.0 11.0 58.0 89.0 67.3 289.6 217.8 270.4 184.7 101.3 137.0    
S.D. 45.5 49.9 8.2 0.0098 0.0045 0.0028 17.5 12.5 23.7 1.9 3.6 0.8 20.2 62.3 9.6 61.0 24.0 8.7 56.8 15.4 10.4    
Normal range 4.4-264 1.0191-1.0891 0-90.51 1.8-16.2 0-165.8 79.1-502.7 24.6-336.2    
  1. RBC Erythorocyte count, WBC Lymphocyte count, AST Aspartate transminase, ALT Alanine transminase, Ketone Ketone body, Bil Biliyubin, Oc. Bld Occult blood, Urobil Urobilinogen, U.Vol Urine body, S.Grav Specific gravity