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Table 2 Safety evaluation by blood tests and blood chemistry examinations at 1, 2 and 4 weeks and urinalysis at 2 and 4 weeks after the transplantation of hypoxia-preconditioned dental pulp stem cells (hpDPSCs)

From: Characterization of stable hypoxia-preconditioned dental pulp stem cells compared with mobilized dental pulp stem cells for application for pulp regenerative therapy

Blood tests

Individual number

RBC (106/μL)

WBC (103/μL)

Platelet count (103/μL)

Hematocrit (%)

        

pre

7

14

28

pre

7

14

28

pre

7

14

28

pre

7

14

28

        

control

6.83

6.66

6.28

6.73

10.61

10.41

10.79

15.77

213

200

183

233

45.2

44.2

42.1

44.0

        

1

6.38

6.54

6.16

5.86

9.13

10.04

9.91

9.37

230

223

260

235

41.9

42.8

40.6

38.8

        

2

6.62

6.83

6.88

6.20

10.40

9.75

11.26

10.00

296

302

290

264

42.7

44.0

44.2

40.1

        

3

7.12

6.73

6.94

7.51

8.06

8.49

8.72

8.50

258

252

266

269

46.2

44.2

45.3

48.5

        

average

6.71

6.70

6.66

6.52

9.20

9.43

9.96

9.29

261.33

259.00

272.00

256.00

43.60

43.67

43.37

42.47

        

S.D.

0.31

0.12

0.35

0.71

0.96

0.67

1.04

0.61

27.05

32.63

12.96

14.99

1.87

0.62

2.01

4.30

        

Normal range

5.10-7.47

6.49-16.61

229-401

33.95-47.67

        

Blood Chemistry examination

Individual number

AST (IU/L)

ALT (IU/L)

Albumin (g/dL)

Globuline (g/dL)

Total choresterol (mg/dL)

Glucose (mg/dL)

pre

7

14

28

pre

7

14

28

pre

7

14

28

pre

7

14

28

pre

7

14

28

pre

7

14

28

control

25

27

25

24

41

40

41

35

3.2

3.1

3.1

2.9

2.2

2.1

2.0

2.3

178

182

170

201

94

94

98

93

1

26

23

23

31

55

56

54

91

3.0

2.9

2.9

2.8

2.1

2.5

2.2

2.1

139

157

151

139

94

98

82

88

2

22

20

22

21

45

48

47

44

3.3

3.3

3.4

3.2

2.2

2.3

2.1

2.0

137

150

142

124

94

102

102

98

3

44

27

28

27

42

45

46

48

3.4

3.3

3.3

3.3

2.1

2.1

2.0

2.2

155

149

140

143

87

98

94

95

average

30.7

23.3

24.3

26.3

47.3

49.7

49.0

61.0

3.2

3.2

3.2

3.1

2.1

2.3

2.1

2.1

143.7

152.0

144.3

135.3

91.7

99.3

92.7

93.7

S.D.

9.57

2.87

2.62

4.11

5.56

4.64

3.56

21.28

0.17

0.19

0.22

0.22

0.05

0.16

0.08

0.08

8.06

3.56

4.78

8.18

3.30

1.89

8.22

4.19

Normal range

19-39

20.8-58.8

2.67-3.43

1.8-3.08

101.2-187.6

85.6-110.4

Urinalysis

Individual number

Color

pH

Ketone

Bil

Oc.Bld

Urobil

      

pre

13

27

pre

13

27

pre

13

27

pre

13

27

pre

13

27

pre

13

27

      

control

0.0

0.0

0.0

6.5

6.0

6.0

0.0

0.0

0.0

1.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

0.0

      

1

0.0

0.0

0.0

8.5

7.5

7.5

0.0

0.0

0.0

1.0

1.0

0.0

0.0

0.0

4.0

0.0

0.0

0.0

      

2

0.0

0.0

0.0

7.0

7.0

7.0

0.0

0.0

0.0

1.0

0.0

1.0

0.0

0.0

0.0

0.0

0.0

0.0

      

3

0.0

0.0

0.0

8.0

8.0

6.5

0.0

0.0

0.0

1.0

0.0

1.0

0.0

0.0

0.0

0.0

0.0

1.0

      

average

0.0

0.0

0.0

7.8

7.5

7.0

0.0

0.0

0.0

1.0

0.3

0.7

0.0

0.0

1.3

0.0

0.0

0.3

      

S.D.

0.0

0.0

0.0

0.6

0.4

0.4

0.0

0.0

0.0

0.0

0.5

0.5

0.0

0.0

1.9

0.0

0.0

0.5

      

Normal range

0.0

5.5-8.5

0-1

0-2

0-3

0-1

      

Urinalysis

Individual number

U.Vol

S.Grav

Protein(mg/dL)

Glucose (mg/dL)

Na (mEq/L)

K (mEq/L)

Cl (mEq/L)

   

pre

13

27

pre

13

27

pre

13

27

pre

13

27

pre

13

27

pre

13

27

pre

7

14

   

control

140

240

98

1.047

1.030

1.050

13.4

7.6

24.2

8.0

8.0

9.0

55

37

48

195.6

140.1

248.8

117

54

113

   

1

60

60

115

1.072

1.046

1.050

48.7

41.3

72.4

10.0

7.0

11.0

49

177

72

366.1

243.1

270.9

260

116

151

   

2

100

140

135

1.060

1.037

1.050

12.4

17.1

15.2

10.0

14.0

10.0

86

48

76

285.7

185.5

259.6

171

80

126

   

3

170

180

127

1.048

1.047

1.056

11.0

13.0

34.9

6.0

6.0

12.0

39

42

54

216.9

224.7

280.8

123

108

134

   

average

110.0

126.7

125.7

1.0600

1.0433

1.0520

24.0

23.8

40.8

8.7

9.0

11.0

58.0

89.0

67.3

289.6

217.8

270.4

184.7

101.3

137.0

   

S.D.

45.5

49.9

8.2

0.0098

0.0045

0.0028

17.5

12.5

23.7

1.9

3.6

0.8

20.2

62.3

9.6

61.0

24.0

8.7

56.8

15.4

10.4

   

Normal range

4.4-264

1.0191-1.0891

0-90.51

1.8-16.2

0-165.8

79.1-502.7

24.6-336.2

   
  1. RBC Erythorocyte count, WBC Lymphocyte count, AST Aspartate transminase, ALT Alanine transminase, Ketone Ketone body, Bil Biliyubin, Oc. Bld Occult blood, Urobil Urobilinogen, U.Vol Urine body, S.Grav Specific gravity