TY - JOUR AU - Krull, Ashley A. AU - Setter, Deborah O. AU - Gendron, Tania F. AU - Hrstka, Sybil C. L. AU - Polzin, Michael J. AU - Hart, Joseph AU - Dudakovic, Amel AU - Madigan, Nicolas N. AU - Dietz, Allan B. AU - Windebank, Anthony J. AU - van Wijnen, Andre J. AU - Staff, Nathan P. PY - 2021 DA - 2021/03/18 TI - Alterations of mesenchymal stromal cells in cerebrospinal fluid: insights from transcriptomics and an ALS clinical trial JO - Stem Cell Research & Therapy SP - 187 VL - 12 IS - 1 AB - Mesenchymal stromal cells (MSCs) have been studied with increasing intensity as clinicians and researchers strive to understand the ability of MSCs to modulate disease progression and promote tissue regeneration. As MSCs are used for diverse applications, it is important to appreciate how specific physiological environments may stimulate changes that alter the phenotype of the cells. One need for neuroregenerative applications is to characterize the spectrum of MSC responses to the cerebrospinal fluid (CSF) environment after their injection into the intrathecal space. Mechanistic understanding of cellular biology in response to the CSF environment may predict the ability of MSCs to promote injury repair or provide neuroprotection in neurodegenerative diseases. SN - 1757-6512 UR - https://doi.org/10.1186/s13287-021-02241-9 DO - 10.1186/s13287-021-02241-9 ID - Krull2021 ER -