Fig. 4

Expression levels of detectable transcripts of genes encoding key immunomodulatory, angiogenic, and neurotrophic factors by MSCs cultured in CM, PLF, and aCSF. a Detectable expression levels (FPKM) of genes encoding immunosuppressive and inflammatory factors (n = 12). b Expression levels (FPKM) of genes encoding select angioneurins and growth factors that are highly expressed by aCSF-treated MSCs (n = 12). c In vitro levels of VEGF protein in MSC cultures in CM, PLF, and aCSF. Data presented with mean ± standard deviation. The Kruskal-Wallis test with Dunn’s test to correct for multiple comparisons were performed to determine statistical significance (* indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001; **** indicates p < 0.0001)