Fig. 11

Antifibrotic effect of MSCs at 8 weeks after inducing AAN in mice. a Immunohistochemical staining for Col-1, b α-SMA, and c p-SMAD2 in kidney tissues from the sham+saline, sham+MSC, AAN-saline, and AAN-MSC groups. The magnification for Col-1, α-SMA, and p-SMAD2 staining was 400X (scale bar, 400 μm). Immunohistochemical staining confirmed the downregulation of fibrosis indexes in the AAN-MSC group compared with the AAN-saline group. Data are presented as the means ± SEM (n = 8). *P < 0.05 for the comparison between AAN-saline and AAN-MSC mice