Fig. 2
Therapeutic effect of MSC-Exo on OVA/CFA-induced SSRA in mice. a The experimental flowchart of construction of mouse model and MSC-Exo treatment. b The change of respiratory system resistance in response to different doses of methacholine. c The change of respiratory system resistance in response to 50 mg/ml methacholine. d The change of lung dynamic compliance in response to different doses of methacholine. e The change of lung dynamic compliance in response to 50 mg/ml methacholine. f Flow cytometry analysis of neutrophils (CD11b+Ly6G+) in BAL fluid. g H&E staining and histological score evaluation on lung tissues. Above: magnification, × 200; below: magnification, × 400. Data are presented as the mean ± SEM (n = 3) (#p < 0.05, ##p < 0.01, ###p < 0.001 vs. the control group; *p < 0.05, **p < 0.01, ***p < 0.001 vs. the OVA/CFA group)