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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization

Fig. 3

The therapeutic effect of MSC-Exo on OVA/CFA-induced SSRA asthmatic mice is macrophage-dependent. a The experimental schematic of macrophage depletion experiment. b Flow cytometry analysis of macrophages (F4/80+CD11b+) in the lung, peritoneal fluid, and spleen from different groups. c The change of respiratory system resistance in response to increasing concentrations of methacholine. d The change of respiratory system resistance in response to 50 mg/ml methacholine. e The change of lung dynamic compliance in response to increasing concentrations of methacholine. f The change of lung dynamic compliance in response to 50 mg/ml methacholine. g H&E staining and histological score evaluation on lung tissues. Data are presented as the mean ± SEM (n = 3) (*p < 0.05, **p < 0.01, ***p < 0.001 vs. the OVA/CFA+P-lipo group)

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