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Table 5 Levels of AST, ALT, ALB, TBIL, ALP, GGT, CREAT, and BUN in the two groups at baseline, day 1, and weeks 1, 2, 4, 8, and 12

From: A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial

  AST ALT ALB TBIL
Rituximab MSC P Rituximab MSC P Rituximab MSC P Rituximab MSC P
Baseline 97.00 (53.00–180.00) 69.00 (21.00–111.00) 0.217 99 (18.00–233.00) 30 (9.00–94.00) 0.171 34.20 (33.20–36.20) 32.20 (30.80–35.80) 0.773 590.07 (202.35–702.68) 420.73 (38.45–541.73) 0.116
Day 1 794.00 (342.00–1032.00) 782.00 (308.00–2120.00) 0.748 355.00 (148.00–852.00) 380.00 (259.00–935.00) 0.652 35.10 (31.50–37.00) 33.90 (30.90–35.40) 0.411 163.07 (92.93–316.96) 119.00 (39.70–167.06) 0.193
Week1 45.00 (20.00–88.00) 34.00 (24.00–34.00) 0.898 106.00 (24.00–217.00) 79.00 (58.00–219.00) 0.652 35.50 (31.90–40.40) 34.30 (31.10–36.30) 0.263 48.69 (39.30–158.60) 41.64 (15.07–86.92) 0.365
Week2 33.00 (15.25–60.25) 18.50 (12.50–37.25) 0.387 67.50 (19.50–176.25) 36.00 (17.50–116.00) 0.426 36.10 (33.40–38.70) 36.90 (34.73–40.48) 0.644 42.05 (23.73–81.29) 19.87 (15.04–42.11) 0.314
Week4 38.00 (21.00–124.00) 28.00 (17.00–36.00) 0.261 49.00 (26.00–158.00) 28.00 (17.50–55.50) 0.295 39.10 (36.60–42.60) 45.40 (40.90–47.45) 0.01* 20.87 (17.14–56.74) 18.87 (11.00–28.58) 0.412
Week8 43.00 (19.00–67.00) 18.00 (14.50–39.00) 0.112 30.00 (16.00–158.00) 28.00 (15.50–91.50) 0.766 43.20 (37.50–44.50) 44.20 (41.60–47.50) 0.152 20.07 (12.70–53.24) 12.80 (8.90–15.51) 0.112
Week12 28.00 (20.00–32.00) 21.00 (18.00–40.00) 0.489 20.00 (13.00–50.50) 21.00 (13.50–96.50) 0.73 40.70 (38.85–45.65) 42.60 (41.85–46.30) 0.245 12.48 (8.42–25.97) 10.00 (9.45–12.40) 0.387
Baseline 99.00 (71.00–116.00) 99.00 (95.00–124.00) 0.478 51.00 (42.00–75.00) 49.00 (33.00–77.00) 1 71.00 (56.00–174.00) 76.00 (45.00–114.00) 0.748 5.35 (3.18–15.44) 7.73 (5.01–9.16) 0.699
Day1 63.00 (45.00–89.00) 65.00 (50.00–73.00) 0.478 51.00 (22.00–62.00) 45.00 (34.00–51.00) 1 105.00 (72.00–183.00) 92.00 (79.00–201.00) 1 11.79 (9.36–19.33) 14.28 (13.45–16.18) 0.519
Week1 68.00 (59.00–181.00) 82.00 (59.00–103.00) 0.949 78.00 (39.00–279.00) 149.00 (64.00–203.00) 0.949 54.00 (44.00–124.00) 60.00 (48.00–84.00) 0.898 17.84 (11.15–30.88) 14.68 (8.19–17.85) 0.27
Week2 99.50 (70.50–135.75) 67.00 (47.50–95.50) 0.24 103.50 (76.00–215.25) 61.50 (35.75–139.00) 0.705 68.50 (48.50–112.50) 49.50 (45.00–56.25) 0.282 14.48 (9.56–21.76) 10.97 (7.87–17.21) 0.152
Week4 105.00 (75.00–208.00) 82.00 (64.50–97.50) 0.112 78.00 (30.00–218.00) 67.00 (36.00–132.00) 0.656 66.00 (47.00–90.00) 62.00 (58.50–73.00) 0.656 8.78 (6.67–10.48) 6.40 (5.81–9.89) 0.503
Week8 125.00 (102.00–226.00) 90.00 (73.00–117.00) 0.056 95.00 (50.00–361.00) 55.00 (28.50–60.00) 0.031* 83.00 (56.00–177.00) 68.00 (57.50–95.00) 0.261 11.10 (4.32–16.94) 7.56 (6.56–10.06) 0.503
Week12 86.00 (69.00–111.50) 87.00 (62.50–130.50) 1 78.00 (42.00–272.00) 35.00 (21.00–92.50) 0.094 80.00 (73.50–127.00) 77.00 (62.50–95.00) 0.436 5.80 (5.21–11.12) 7.70 (6.68–8.32) 0.077
  1. *P < 0.05
  2. Abbreviations: AST aspartate aminotransferase, ALT alanine aminotransferase, ALB albumin, TBIL total bilirubin, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, CREAT creatinine, BUN blood urea nitrogen, MSC mesenchymal stem cell