Table 5 Levels of AST, ALT, ALB, TBIL, ALP, GGT, CREAT, and BUN in the two groups at baseline, day 1, and weeks 1, 2, 4, 8, and 12
From: A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial
| |
AST
|
ALT
|
ALB
|
TBIL
|
|---|
|
Rituximab
|
MSC
|
P
|
Rituximab
|
MSC
|
P
|
Rituximab
|
MSC
|
P
|
Rituximab
|
MSC
|
P
|
|---|
|
Baseline
|
97.00 (53.00–180.00)
|
69.00 (21.00–111.00)
|
0.217
|
99 (18.00–233.00)
|
30 (9.00–94.00)
|
0.171
|
34.20 (33.20–36.20)
|
32.20 (30.80–35.80)
|
0.773
|
590.07 (202.35–702.68)
|
420.73 (38.45–541.73)
|
0.116
|
|
Day 1
|
794.00 (342.00–1032.00)
|
782.00 (308.00–2120.00)
|
0.748
|
355.00 (148.00–852.00)
|
380.00 (259.00–935.00)
|
0.652
|
35.10 (31.50–37.00)
|
33.90 (30.90–35.40)
|
0.411
|
163.07 (92.93–316.96)
|
119.00 (39.70–167.06)
|
0.193
|
|
Week1
|
45.00 (20.00–88.00)
|
34.00 (24.00–34.00)
|
0.898
|
106.00 (24.00–217.00)
|
79.00 (58.00–219.00)
|
0.652
|
35.50 (31.90–40.40)
|
34.30 (31.10–36.30)
|
0.263
|
48.69 (39.30–158.60)
|
41.64 (15.07–86.92)
|
0.365
|
|
Week2
|
33.00 (15.25–60.25)
|
18.50 (12.50–37.25)
|
0.387
|
67.50 (19.50–176.25)
|
36.00 (17.50–116.00)
|
0.426
|
36.10 (33.40–38.70)
|
36.90 (34.73–40.48)
|
0.644
|
42.05 (23.73–81.29)
|
19.87 (15.04–42.11)
|
0.314
|
|
Week4
|
38.00 (21.00–124.00)
|
28.00 (17.00–36.00)
|
0.261
|
49.00 (26.00–158.00)
|
28.00 (17.50–55.50)
|
0.295
|
39.10 (36.60–42.60)
|
45.40 (40.90–47.45)
|
0.01*
|
20.87 (17.14–56.74)
|
18.87 (11.00–28.58)
|
0.412
|
|
Week8
|
43.00 (19.00–67.00)
|
18.00 (14.50–39.00)
|
0.112
|
30.00 (16.00–158.00)
|
28.00 (15.50–91.50)
|
0.766
|
43.20 (37.50–44.50)
|
44.20 (41.60–47.50)
|
0.152
|
20.07 (12.70–53.24)
|
12.80 (8.90–15.51)
|
0.112
|
|
Week12
|
28.00 (20.00–32.00)
|
21.00 (18.00–40.00)
|
0.489
|
20.00 (13.00–50.50)
|
21.00 (13.50–96.50)
|
0.73
|
40.70 (38.85–45.65)
|
42.60 (41.85–46.30)
|
0.245
|
12.48 (8.42–25.97)
|
10.00 (9.45–12.40)
|
0.387
|
|
Baseline
|
99.00 (71.00–116.00)
|
99.00 (95.00–124.00)
|
0.478
|
51.00 (42.00–75.00)
|
49.00 (33.00–77.00)
|
1
|
71.00 (56.00–174.00)
|
76.00 (45.00–114.00)
|
0.748
|
5.35 (3.18–15.44)
|
7.73 (5.01–9.16)
|
0.699
|
|
Day1
|
63.00 (45.00–89.00)
|
65.00 (50.00–73.00)
|
0.478
|
51.00 (22.00–62.00)
|
45.00 (34.00–51.00)
|
1
|
105.00 (72.00–183.00)
|
92.00 (79.00–201.00)
|
1
|
11.79 (9.36–19.33)
|
14.28 (13.45–16.18)
|
0.519
|
|
Week1
|
68.00 (59.00–181.00)
|
82.00 (59.00–103.00)
|
0.949
|
78.00 (39.00–279.00)
|
149.00 (64.00–203.00)
|
0.949
|
54.00 (44.00–124.00)
|
60.00 (48.00–84.00)
|
0.898
|
17.84 (11.15–30.88)
|
14.68 (8.19–17.85)
|
0.27
|
|
Week2
|
99.50 (70.50–135.75)
|
67.00 (47.50–95.50)
|
0.24
|
103.50 (76.00–215.25)
|
61.50 (35.75–139.00)
|
0.705
|
68.50 (48.50–112.50)
|
49.50 (45.00–56.25)
|
0.282
|
14.48 (9.56–21.76)
|
10.97 (7.87–17.21)
|
0.152
|
|
Week4
|
105.00 (75.00–208.00)
|
82.00 (64.50–97.50)
|
0.112
|
78.00 (30.00–218.00)
|
67.00 (36.00–132.00)
|
0.656
|
66.00 (47.00–90.00)
|
62.00 (58.50–73.00)
|
0.656
|
8.78 (6.67–10.48)
|
6.40 (5.81–9.89)
|
0.503
|
|
Week8
|
125.00 (102.00–226.00)
|
90.00 (73.00–117.00)
|
0.056
|
95.00 (50.00–361.00)
|
55.00 (28.50–60.00)
|
0.031*
|
83.00 (56.00–177.00)
|
68.00 (57.50–95.00)
|
0.261
|
11.10 (4.32–16.94)
|
7.56 (6.56–10.06)
|
0.503
|
|
Week12
|
86.00 (69.00–111.50)
|
87.00 (62.50–130.50)
|
1
|
78.00 (42.00–272.00)
|
35.00 (21.00–92.50)
|
0.094
|
80.00 (73.50–127.00)
|
77.00 (62.50–95.00)
|
0.436
|
5.80 (5.21–11.12)
|
7.70 (6.68–8.32)
|
0.077
|
- *P < 0.05
- Abbreviations: AST aspartate aminotransferase, ALT alanine aminotransferase, ALB albumin, TBIL total bilirubin, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, CREAT creatinine, BUN blood urea nitrogen, MSC mesenchymal stem cell
