TY - JOUR AU - Teng, Yuan-chi AU - Porfírio-Sousa, Alfredo Leonardo AU - Ribeiro, Giulia Magri AU - Arend, Marcela Corso AU - da Silva Meirelles, Lindolfo AU - Chen, Elizabeth Suchi AU - Rosa, Daniela Santoro AU - Han, Sang Won PY - 2021 DA - 2021/03/16 TI - Analyses of the pericyte transcriptome in ischemic skeletal muscles JO - Stem Cell Research & Therapy SP - 183 VL - 12 IS - 1 AB - Peripheral arterial disease (PAD) affects millions of people and compromises quality of life. Critical limb ischemia (CLI), which is the most advanced stage of PAD, can cause nonhealing ulcers and strong chronic pain, and it shortens the patients’ life expectancy. Cell-based angiogenic therapies are becoming a real therapeutic approach to treat CLI. Pericytes are cells that surround vascular endothelial cells to reinforce vessel integrity and regulate local blood pressure and metabolism. In the past decade, researchers also found that pericytes may function as stem or progenitor cells in the body, showing the potential to differentiate into several cell types. We investigated the gene expression profiles of pericytes during the early stages of limb ischemia, as well as the alterations in pericyte subpopulations to better understand the behavior of pericytes under ischemic conditions. SN - 1757-6512 UR - https://doi.org/10.1186/s13287-021-02247-3 DO - 10.1186/s13287-021-02247-3 ID - Teng2021 ER -