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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Reprogrammed mesenchymal stem cells derived from iPSCs promote bone repair in steroid-associated osteonecrosis of the femoral head

Fig. 4

DNA methylation analysis. a The median level of all CpG sites (black line represents median). b Statistics of CpG sites with different methylation status. c Number of CpGs with differential DNAm between normal BMSCs, ONFH-BMSCs and iPSC-MSCs (p < 0.05); hypermethylated CpGs (red), hypomethylationare CpGs (blue). d Heatmap analysis of 13,432 CpG sites with differential DNAm in normal BMSCs, ONFH-BMSCs, and iPSC-MSCs demonstrated that ONFH-associated DNAm pattern is erased upon reprogramming and not reestablished in iPSC-MSCs. P passage; D donor

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Stem Cell Research & Therapy

ISSN: 1757-6512