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Table 2 Robo1 BiCAR- NK92-mediated immunotherapy tested in phase I/II clinical trials in patients with relapsed and refractory pancreatic cancer

From: Renaissance of armored immune effector cells, CAR-NK cells, brings the higher hope for successful cancer therapy

Clinical trial identifier Target antigen Condition or disease Origin of NK cell Construct Phase Status Location
NCT03824964 CD19/CD22 Refractory B cell lymphoma Allogeneic NK cells Not mentioned Early phase I Not yet recruiting Not mentioned
NCT03940833 BCMA Multiple myeloma NK 92 cells Not mentioned I/II Recruiting Suzhou, Jiangsu, China
NCT02892695 CD19 Lymphoma and leukemia NK 92 cells Not mentioned I/II Unknown Suzhou, Jiangsu, China
NCT03579927 CD19 Lymphoma and leukemia Cord Blood NK Cells CAR.CD19-CD28-zeta-2A-iCasp9-IL15 I/II Not yet recruiting Houston, TX, USA
NCT03692663 PSMA Castration-resistant Prostate Cancer Not specified Not mentioned Early phase I Not yet recruiting Not mentioned
NCT03692637 Mesothelin Epithelial ovarian cancer Not specified Not mentioned Early phase I Not yet recruiting Not mentioned
NCT03941457 ROBO1 Pancreatic cancer Not specified BiCAR-NK cells I/II Recruiting Shanghai, China
NCT03940820 ROBO1 Solid tumor Not specified Not mentioned I/II Recruiting Suzhou, Jiangsu, China
NCT03415100 NKG2D ligands Solid tumors Autologous or allogeneic
NK cells
Not mentioned I Recruiting Guangzhou, Guangdong, China
NCT03056339 CD19 Lymphoma and leukemia (relapsed/refractory B cell malignancy) Umbilical cord blood I CAR.CD19-CD28-zeta-2A-iCasp9-IL15 I/II Recruiting Houston, TX, USA
NCT02944162 CD33 Acute myeloid leukemia (AML) NK 92 cells CAR.CD28, CD137 and CD3 zeta I/II Unknown Suzhou, Jiangsu, China
NCT03931720 ROBO1 Malignant tumor Not specified BiCAR-NK/T cells I/II Recruiting Suzhou, Jiangsu, China
NCT03692767 CD22 Refractory B cell lymphoma Allogeneic NK cells Not mentioned Early phase I Not yet recruiting Not mentioned
NCT03690310 CD19 Refractory B cell lymphoma Allogeneic NK cells Not mentioned Early phase I Not yet recruiting Not mentioned
NCT01974479 CD19 All Haploidentical donor NK cells Not mentioned I Suspended Singapore
NCT00995137 CD19 All Expanded donor NK cells Not mentioned I Completed Memphis, TN, USA