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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Apoptosis repressor with caspase recruitment domain (ARC) promotes bone regeneration of bone marrow-derived mesenchymal stem cells by activating Fgf-2/PI3K/Akt signaling

Fig. 4

Histological analysis of the new bone formation area and remnant scaffold area in the calvarial defects. a The specimens were stained with Van Gieson’s picro fuchsin (original magnification, × 1.25, × 40). b Statistical analysis of newly formed bone tissues in each group at × 40. The percentage of new bone area was 5.135 ± 0.2263% in the CPC group, 22.36 ± 1.413% in the BMSC-CON group, and 31.64 ± 1.530% in the BMSC-NOL3 group (**p < 0.01). c Percentage of remnant scaffold area in each group at × 40. The percentage of remnant scaffolds was 30.00 ± 1.033% in the CPC group, 28.75 ± 0.8619% in the BMSC-CON group, and 31.46 ± 1.961% in the BMSC-NOL3 group, and no significant difference was found among these groups. d New bone formation and mineralization were determined by histomorphometric analysis using TE, CA, and AL fluorescent quantification, which represents the mineralization level at different time periods. e Percentage of the fluorochrome-stained bone area in each group

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Stem Cell Research & Therapy

ISSN: 1757-6512