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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Apoptosis repressor with caspase recruitment domain (ARC) promotes bone regeneration of bone marrow-derived mesenchymal stem cells by activating Fgf-2/PI3K/Akt signaling

Fig. 5

a Geometric mean-centered, hierarchical clustering heat map from microarray data: 533 differentially expressed genes were detected between the BMSC-CON and BMSC-NOL3 groups; 233 genes were upregulated, while 322 genes were downregulated in the BMSC-NOL3 group. b Differentially expressed gene-protein interaction (ppi) network diagram; the blue round node indicates upregulated gene expression, and the green diamond node indicates downregulated gene expression. c RT-PCR analysis of Fgf-2 gene expression between the BMSC-CON and BMSC-NOL3 groups. d RT-PCR analysis of osteogenic genes, including OCN, Runx2, and ALP, after BGJ398, an FGFR inhibitor, treatment. e, f WB analysis of p-PI3K and p-Akt protein expression between the BMSC-CON and BMSC-NOL3 groups

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