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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: EIF5A2 enhances stemness of epithelial ovarian cancer cells via a E2F1/KLF4 axis

Fig. 1

EIF5A2 is upregulated in EOC specimens and its expression is associated with chemo-resistance and poor prognosis. A qRT-PCR was used to detect the expression of EIF5A2 in 30 EOC tissues and 18 normal control tissues. B Western-blot assay bands of 20 pairs primary tissues and MCAs in ascites of EOC patients using Image J. C Quantitation of protein expression. Statistical analysis was performed using Student’s t test. D Immunohistochemical staining was used to detect the expression of EIF5A2 in 76 EOC tissue samples. Scale bar = 50 μm. (a) Normal expression of EIF5A2 was observed in a normal epithelium of fallopian tube tissue. (b) Low-expression of EIF5A2 was detected in an ovarian carcinoma (case 24). (c) Overexpression of EIF5A2 was detected in an ovarian carcinoma (case 28), in which about 60% of tumor cells showed moderate positive staining of EIF5A2. (d) Another ovarian carcinoma (case 45) showed overexpression of EIF5A2, in which 90% of tumor cells had strong positive staining of EIF5A2. E Kaplan-Meier analysis of EOC patients with low- or high-EIF5A2 expression. F The association of EIF5A2 expression with EOC patients’ survival in 1657 advanced EOC patients from GEO and TCGA database. All the data represent the means ± SD; *p < 0.05, **p < 0.01, and ***p < 0.001

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