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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model

Fig. 4

hAECs promoted the collagen degradation through increasing the expression of MMP-8. A Masson staining results showed less collagen deposition (stained blue) around the uterine scar in the hAECs group (i, l) compared with the PBS group (e, k). Scale bar = 200 μm. B IHC staining was used to detect the expression of MMP-8 in the uterine scars at day 30 and 60 post-transplantation in the sham group, PBS group, and hAECs group (n = 8 uterine horns per group). Scale bar = 25 μm. C The MMP-8 expression was semi-quantified by calculating the positive cells per field under a magnification of × 400. D Western blot analysis showed the MMP-8 expression of the uterine scars in the hAECs group and PBS group at day 5 after injection of hAECs or PBS. E The grayscale values of the western blots were evaluated. The protein level of MMP-8 was normalized to that of β-tubulin (n = 5; **P < 0.01; ***P < 0.001)

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