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Table 2 Summary of MSC source, injury type, and main findings from the treatment of RISI using MSCs in preclinical studies

From: Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?

Publication Animal model MSC source Injury type Main findings Reference
Rong et al. 2019 Sprague-Dawley rat Human fetal skin-derived stem cell Radiation-induced skin injury Enhanced radiation dermatitis angiogenesis [1]
Kakabadze et al. 2019 Lewis inbred rats Rat bone marrow Nonhealing wounds of radiation Closing the burn wound increased the rate of healing [4]
Myung et al. 2019 SKH-1 hairless mice Umbilical cord blood-derived Combined radiation and wound injury UCB-MSCs+PRP improve regeneration efficacy by enhancing angiogenesis [7]
Wu et al. 2018 Nude mice Adipose-derived stem Cutaneous punch wounds with radiation exposure Revitalized irradiated tissues and accelerated wound healing [10]
Sun et al. 2018 Sprague-Dawley rat WJ-MSCs Radiation-induced skin injury Accelerated wound closure and enhanced the wound healing quality [16]
Liu et al. 2018 SD rats Human umbilical cord Irradiation-induced skin ulcers Promoted neovascularization and reepithelization, and improved healing of irradiation-induced skin ulcers [13]
Lee et al. 2017 Male C57BL/6 mice Human umbilical cord blood-derived Combined radiation wound Enhanced wound healing and angiogenesis in the wound site [15]
Riccobono et al. 2016 Minipigs Adipose tissue-derived stromal/stem cells Cutaneous radiation syndrome Have an effect on both muscle inflammation and regeneration [20]
Jin et al. 2016 Sprague-Dawley rat Rat MSCs+PDGF Radiation-induced skin ulceration Radiation-induced skin ulceration [22]
Rodriguez-Menocal et al. 2015 C57BL/6 mice Whole bone marrow, whole bone marrow cultured cells, MSCs Radiation-induced delayed wound Mixed bone marrow cell preparations may be superior to a more purified stem cell formulation in stimulating wound healing [23]
Horton et al. 2013 C3H/HeN mice Syngeneic or allogeneic BMSC IR-induced fibrosis Alter the progression of radiation-induced fibrosis by altering macrophage phenotype and suppressing local inflammation [61]
Huang et al. 2013 Sprague-Dawley rat Adipose-derived stem cells Acute radiation ulcers Contributed to vascularization by acting as angiogenesis-promoting cells [26]
Forcheron et al. 2012 Minipigs Autologous adipose MSCs Cutaneous radiation syndrome Attracted numerous immune cells and accumulated at the dermis/subcutis barrier [27]
Agay et al. 2010 Minipig Autologous bone marrow Cutaneous radiation syndrome Led to local accumulation of lymphocytes and improved vascularization [30]
Riccobono et al. 2012 Minipig Adipocyte-derived stem cells Cutaneous radiation syndrome Improved wound healing [32]
Horton et al. 2013 Female C3H/HEN mice Mouse bone marrow Cutaneous radiation syndrome Reduced inflammation and fibrosis [33]
Zheng et al. 2015 Sprague-Dawley rat Rat bone marrow Radiation-induced skin injury Reduced inflammation, decreased expression of PGE2 and TGF-β1 [38]
Xia et al. 2014 Sprague-Dawley rat Rat bone marrow MSCs expressing human VEGF and beta-defensin-3 Radiation and excisional injury Improved skin appendage regeneration and collagen deposition; shortened wound healing duration [45]
Xie et al. 2013 C3Hf/Kam female and C57Bl/6 male gnotobiotic mice Murine bone Radiation-induced wound Haptized collagen strips to reduce radiation wound-healing deficits [54]
Kotenko et al. 2012 Male Wistar rats Rats bone marrow Radiation skin damage Normalize intercellular interaction and influence the processes of proliferation and differentiation of skin cells [8]
Yan et al. 2011 Minipigs MSCs expressing hPDGF loaded onto acellular amniotic membrane Radiation and excisional injury Improved granulation, re-epithelialization and angiogenesis [62]
Ebrahimian et al. 2009 C57Bl/6 male mice Homogenous ADSCs Skin punched wounds and then irradiated Promoted dermal wound healing and enhanced wound closure [63]
Hao et al. 2008 Sprague-Dawley rat Rat bone marrow MSCs expressing human PDGF and beta-defensin-2 Radiation and excisional injury Improved granulation tissue formation and reduced bacterial load [64]
Francois et al. 2007; Mouiseddine et al. 2007 NOD/SCID mice Human bone marrow Radiation dermatitis Improved wound healing [65]