Table 2 Summary of MSC source, injury type, and main findings from the treatment of RISI using MSCs in preclinical studies
From: Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?
Publication | Animal model | MSC source | Injury type | Main findings | Reference |
|---|---|---|---|---|---|
Rong et al. 2019 | Sprague-Dawley rat | Human fetal skin-derived stem cell | Radiation-induced skin injury | Enhanced radiation dermatitis angiogenesis | [1] |
Kakabadze et al. 2019 | Lewis inbred rats | Rat bone marrow | Nonhealing wounds of radiation | Closing the burn wound increased the rate of healing | [4] |
Myung et al. 2019 | SKH-1 hairless mice | Umbilical cord blood-derived | Combined radiation and wound injury | UCB-MSCs+PRP improve regeneration efficacy by enhancing angiogenesis | [7] |
Wu et al. 2018 | Nude mice | Adipose-derived stem | Cutaneous punch wounds with radiation exposure | Revitalized irradiated tissues and accelerated wound healing | [10] |
Sun et al. 2018 | Sprague-Dawley rat | WJ-MSCs | Radiation-induced skin injury | Accelerated wound closure and enhanced the wound healing quality | [16] |
Liu et al. 2018 | SD rats | Human umbilical cord | Irradiation-induced skin ulcers | Promoted neovascularization and reepithelization, and improved healing of irradiation-induced skin ulcers | [13] |
Lee et al. 2017 | Male C57BL/6 mice | Human umbilical cord blood-derived | Combined radiation wound | Enhanced wound healing and angiogenesis in the wound site | [15] |
Riccobono et al. 2016 | Minipigs | Adipose tissue-derived stromal/stem cells | Cutaneous radiation syndrome | Have an effect on both muscle inflammation and regeneration | [20] |
Jin et al. 2016 | Sprague-Dawley rat | Rat MSCs+PDGF | Radiation-induced skin ulceration | Radiation-induced skin ulceration | [22] |
Rodriguez-Menocal et al. 2015 | C57BL/6 mice | Whole bone marrow, whole bone marrow cultured cells, MSCs | Radiation-induced delayed wound | Mixed bone marrow cell preparations may be superior to a more purified stem cell formulation in stimulating wound healing | [23] |
Horton et al. 2013 | C3H/HeN mice | Syngeneic or allogeneic BMSC | IR-induced fibrosis | Alter the progression of radiation-induced fibrosis by altering macrophage phenotype and suppressing local inflammation | [61] |
Huang et al. 2013 | Sprague-Dawley rat | Adipose-derived stem cells | Acute radiation ulcers | Contributed to vascularization by acting as angiogenesis-promoting cells | [26] |
Forcheron et al. 2012 | Minipigs | Autologous adipose MSCs | Cutaneous radiation syndrome | Attracted numerous immune cells and accumulated at the dermis/subcutis barrier | [27] |
Agay et al. 2010 | Minipig | Autologous bone marrow | Cutaneous radiation syndrome | Led to local accumulation of lymphocytes and improved vascularization | [30] |
Riccobono et al. 2012 | Minipig | Adipocyte-derived stem cells | Cutaneous radiation syndrome | Improved wound healing | [32] |
Horton et al. 2013 | Female C3H/HEN mice | Mouse bone marrow | Cutaneous radiation syndrome | Reduced inflammation and fibrosis | [33] |
Zheng et al. 2015 | Sprague-Dawley rat | Rat bone marrow | Radiation-induced skin injury | Reduced inflammation, decreased expression of PGE2 and TGF-β1 | [38] |
Xia et al. 2014 | Sprague-Dawley rat | Rat bone marrow MSCs expressing human VEGF and beta-defensin-3 | Radiation and excisional injury | Improved skin appendage regeneration and collagen deposition; shortened wound healing duration | [45] |
Xie et al. 2013 | C3Hf/Kam female and C57Bl/6 male gnotobiotic mice | Murine bone | Radiation-induced wound | Haptized collagen strips to reduce radiation wound-healing deficits | [54] |
Kotenko et al. 2012 | Male Wistar rats | Rats bone marrow | Radiation skin damage | Normalize intercellular interaction and influence the processes of proliferation and differentiation of skin cells | [8] |
Yan et al. 2011 | Minipigs | MSCs expressing hPDGF loaded onto acellular amniotic membrane | Radiation and excisional injury | Improved granulation, re-epithelialization and angiogenesis | [62] |
Ebrahimian et al. 2009 | C57Bl/6 male mice | Homogenous ADSCs | Skin punched wounds and then irradiated | Promoted dermal wound healing and enhanced wound closure | [63] |
Hao et al. 2008 | Sprague-Dawley rat | Rat bone marrow MSCs expressing human PDGF and beta-defensin-2 | Radiation and excisional injury | Improved granulation tissue formation and reduced bacterial load | [64] |
Francois et al. 2007; Mouiseddine et al. 2007 | NOD/SCID mice | Human bone marrow | Radiation dermatitis | Improved wound healing | [65] |