Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?

Table 3 Summary of MSC source, injury type, and main findings from the treatment of RISI using MSCs in clinical applications

Publication	MSC source	Combined treatment	Injury type	Main findings	Reference
Portas et al. 2016	Allogenic cadaveric bone marrow	Surgical methods, hyperbaric oxygen treatment	Radiation-induced chronic skin lesions	Ulcer dimensions were reduced and remission of signs and symptoms	[2]
Guo et al. 2014	Allogeneic bone marrow	HLA-mismatched peripheral blood stem cell transplantation	Radioactive skin ulceration	Suggesting a potential benefit of MSCs in radiation treatments	[5]
Kotenko et al. 2012	Human bone marrow	Surgery and traditional conservative therapy	Severe local radiation ulcers	Rapid growth of granulation tissue and marginal epithelization and reduction in the ulcer	[8]
Bey et al. 2010	Autologous bone marrow	Skin autograft	Severe radiation burn and radiation dermatitis	Modulating radiation inflammatory processes	[12]
Benderitter et al. 2010	Autologous bone marrow	Plastic surgery or skin graft	Severe radiological burn	Being driven by the quality and the rapidity of the wound healing	[14]
Akita et al. 2010	Autologous adipose tissue	Temporal artificial dermis impregnated+BFGF	Chronic radiation injuries	Wound was healed and no sign of recurrence appeared	[17]
Lataillade et al. 2007	Autologous bone marrow	Surgery	Radiation burn	Open new prospects in radiotherapy complications	[19]

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