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Table 3 Summary of MSC source, injury type, and main findings from the treatment of RISI using MSCs in clinical applications

From: Will mesenchymal stem cells be future directions for treating radiation-induced skin injury?

Publication MSC source Combined treatment Injury type Main findings Reference
Portas et al. 2016 Allogenic cadaveric bone marrow Surgical methods, hyperbaric oxygen treatment Radiation-induced chronic skin lesions Ulcer dimensions were reduced and remission of signs and symptoms [2]
Guo et al. 2014 Allogeneic bone marrow HLA-mismatched peripheral blood stem cell transplantation Radioactive skin ulceration Suggesting a potential benefit of MSCs in radiation treatments [5]
Kotenko et al. 2012 Human bone marrow Surgery and traditional conservative therapy Severe local radiation ulcers Rapid growth of granulation tissue and marginal epithelization and reduction in the ulcer [8]
Bey et al. 2010 Autologous bone marrow Skin autograft Severe radiation burn and radiation dermatitis Modulating radiation inflammatory processes [12]
Benderitter et al. 2010 Autologous bone marrow Plastic surgery or skin graft Severe radiological burn Being driven by the quality and the rapidity of the wound healing [14]
Akita et al. 2010 Autologous adipose tissue Temporal artificial dermis impregnated+BFGF Chronic radiation injuries Wound was healed and no sign of recurrence appeared [17]
Lataillade et al. 2007 Autologous bone marrow Surgery Radiation burn Open new prospects in radiotherapy complications [19]