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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts

Fig. 7

Schematic illustration of the role of CS-EVs on skin rejuvenation. The CS hydrogel load with EVs, a biological particle released by hP-MSC, to the target cells and activate senescent dermal fibroblasts. EVs incorporated with CS hydrogel could activate senescent fibroblasts by improving cellular proliferation, decreasing SA-β-gal activity, promoting ECM synthesis, and inhibiting ECM degradation. Consequently, CS-EVs therapy leads to improved functional recovery to ameliorate skin aging

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Stem Cell Research & Therapy

ISSN: 1757-6512