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Table 1 A brief overview of clinical trials in the context of the MSC-based therapy for immune-mediated disorders registered in ClinicalTrails.gov (January 2021)

From: Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

Condition Study phase Cell source Participant number Location NCT number
GVHD 2/3 BM 200 China NCT02241018
GVHD 2 BM 15 USA NCT00284986
GVHD 1/2 UC 30 China NCT01754454
GVHD 2 n/a 30 Belgium NCT00504803
GVHD 1/2 BM 10 Pakistan NCT02824653
GVHD 1/2 BM 20 Israel NCT00749164
GVHD 2 BM 40 China NCT01765634
GVHD 1 CF 100 China NCT03123458
GVHD 1/2 UC 27 China NCT04213248
GVHD 3 BM 6 Turkey NCT03106662
GVHD 1/2 n/a 25 India NCT00314483
GVHD 1/2 AT 15 Spain NCT02687646
GVHD 1/2 UCB 10 S. Korea NCT00823316
GVHD 3 n/a 260 USA NCT00366145
GVHD 1/2 BM 1 USA NCT02379442
GVHD 13 UCB 30 S. Korea NCT01549665
GVHD 2/3 BM 100 China NCT01526850
GVHD 1/2 AT 19 Spain NCT01222039
GVHD 2 BM 90 Brazil NCT02770430
GVHD 2 BM 70 Russian NCT01941394
GVHD 1 BM 10 S. Korea NCT01318330
GVHD 1 WJ 10 USA NCT03158896
GVHD 1/2 UC 40 Malaysia NCT03847844
SLE 1/2 OM 10 Belarus NCT04184258
SLE 1/2 BM 20 China NCT00698191
SLE 1/2 UC 40 China NCT01741857
SLE 2 UC 81 USA NCT02633163
SLE 1 UC 6 USA NCT03171194
SLE 1/2 UC 10 France NCT03562065
SLE 2 BM 36 Spain NCT03673748
CD 1/2 BM 20 USA NCT04519671
CD 1/2 AT 15 Spain NCT01157650
CD 1/2 UC 82 China NCT02445547
CD 1/2 BM 21 Netherlands NCT01144962
CD 2 BM 10 USA NCT00294112
CD 1/2 BM 20 Belgium NCT01540292
CD 3 AT 278 Austria NCT01541579
CD 3 n/a 98 USA NCT00543374
CD 1 BM 15 USA NCT04073472
CD 1 BM 10 Iran NCT01874015
CD 1/2 UCB 24 S. Korea NCT02000362
RA 1/2 AT 53 Spain NCT01663116
RA 1 BM 15 Iran NCT03333681
RA 1/2 AT 54 USA NCT04170426
RA 1 BM 20 USA NCT03186417
RA 1 UC 16 USA NCT03828344
RA 1/2 UC 200 China NCT01547091
RA 1 UC 40 China NCT02643823
RA 2/3 BM 60 Iran NCT01873625
RA 1/2 BM 20 Panama NCT01985464
RA 1/2 AT 15 USA NCT03691909
OA 1/2 UC 15 Indonesia NCT04314661
OA 1 AT 10 Jordan NCT02966951
OA 1/2 BM 10 Brazil NCT01895413
OA 1/2 BM 24 India NCT01985633
OA 1/2 AT 18 China NCT01809769
OA 1/2 BM 30 Spain NCT01586312
OA 2 BM 32 USA NCT02958267
OA 2 n/a 72 Malaysia NCT01448434
OA 2 BM 40 Iran NCT01504464
OA 2 n/a 60 India NCT01453738
OA 1/2 AT 100 Poland NCT03869229
OA 1/2 BM 30 Spain NCT02123368
OA 3 AT 54 Ecuador NCT04351932
OA 2 UC 60 China NCT03383081
OA 1 AT 4 Taiwan NCT02544802
OA 1 UC 20 China NCT02291926
OA n/a BM 35 USA NCT03014037
OA 3 BM/UC/AT 480 USA NCT03818737
OA 1 UCB 12 S. Korea NCT04037345
OA T BM 12 Spain NCT01183728
OA 2/3 BM 25 Egypt NCT00891501
OA 2 AT 28 USA NCT02674399
OA n/a BM 20 United Kingdom NCT02696876
OA n/a BM 100 USA NCT02582489
OA n/a AT 100 USA NCT03379168
OA 3 UC 103 S. Korea NCT01626677
OA n/a AT 10 USA NCT01739504
OA 1/2 BM/P 45 Ukraine NCT04453111
OA 3 UCB 104 S. Korea NCT01041001
OA 1 UC 125 USA NCT04043819
OA 2 BM 13 Jordan NCT02118519
OA 1/2 WJ 100 Poland NCT03866330
OA n/a BM/PB/AT 35 France NCT01879046
OA 2/3 BM 60 Iran NCT01873625
OA 1/2 AT 18 S. Korea NCT01300598
OA 1/2 BM 15 Taiwan NCT03589287
OA 2 UC 60 China NCT03383081
MS 1/2 UC 69 Trinidad and Tobago NCT02418325
MS 1/2 BM 8 Spain NCT02495766
MS 1/2 UC 60 Jordan NCT03326505
MS 2 n/a 31 Canada NCT02239393
MS 1 BM 7 Sweden NCT03778333
MS 1/2 n/a 20 Italy NCT01854957
MS 1/2 BM 22 Iran NCT01377870
MS 1/2 n/a 15 Sweden NCT01730547
MS 1/2 BM 1 France NCT02403947
MS 1/2 BM 10 United Kingdom NCT00395200
MS 1/2 BM 13 Jordan NCT01895439
MS 1 BM 20 USA NCT01933802
MS 1/2 UC 20 Panama NCT02034188
MS 1/2 BM 9 Spain NCT02035514
MS 1/2 UC 20 China NCT01364246
MS 2 n/a 9 Spain NCT01228266
MS 2 BM 50 USA NCT03355365
MS 2 BM 20 USA NCT03799718
MS 2 BM 48 Israel NCT02166021
ALI/ARDS 1 n/a 70 USA NCT04629105
ALI/ARDS 1/2 UC 75 United Kingdom NCT03042143
ALI/ARDS 1/2 WJ 30 Spain NCT04390139
ALI/ARDS 2 BM 40 Germany NCT04377334
ALI/ARDS 1/2 n/a 24 Australia NCT04537351
ALI/ARDS 1 BM 9 Sweden NCT04447833
ALI/ARDS 1/2 AT 26 Spain NCT04289194
ALI/ARDS 2 BM 10 S. Korea NCT02112500
ALI/ARDS 1 UC 18 Taiwan NCT04347967
ALI/ARDS 1 WJ 9 Mexico NCT04456361
ALI/ARDS 1 AT 20 China NCT01902082
ALI/ARDS 1 UC 10 Mexico NCT04416139
ALI/ARDS 2/3 UC/AT/BM 60 Iran NCT04366063
ALI/ARDS 1/2 UC 20 China NCT02444455
ALI/ARDS 1 WJ 40 Colombia NCT04390152
ALI/ARDS 2 n/a 30 USA NCT04466098
COVID-19 2 UC 16 China NCT04269525
COVID-19 1/2 UC 24 USA NCT04355728
COVID-19 1/2 WJ 30 Spain NCT04390139
COVID-19 1 BM 45 USA NCT04397796
COVID-19 1/2 DP 20 China NCT04336254
COVID-19 n/a UC 48 China NCT04273646
COVID-19 1 WJ 9 Mexico NCT04456361
COVID-19 2 UC 10 Mexico NCT04416139
COVID-19 1 WJ 5 Jordan NCT04313322
COVID-19 1 UC 20 China NCT04252118
COVID-19 1 AT 20 Mexico NCT04611256
COVID-19 2 n/a 90 Brazil NCT04315987
COVID-19 1/2 UC 30 China NCT04339660
COVID-19 1 UC 70 USA NCT04565665
COVID-19 2 UC 100 China NCT04288102
COVID-19 1 UC 40 USA NCT04573270
COVID-19 2/3 BM/UC/AT 60 Iran NCT04366063
COVID-19 1 n/a 70 USA NCT04629105
COVID-19 1/2 AT 24 Spain NCT04366323
COVID-19 1/2 OM 40 Belarus NCT04382547
COVID-19 2 UC 102 Spain NCT04366271
COVID-19 1 UC 40 Indonesia NCT04457609
COVID-19 1/2 WJ 40 Colombia NCT04390152
COVID-19 2 BM 40 Germany NCT04377334
COVID-19 1/2 UC/P 30 Ukraine NCT04461925
COVID-19 1/2 UC 24 USA NCT04355728
COVID-19 3 n/a 300 USA NCT04371393
COVID-19 2 n/a 30 USA NCT04466098
COVID-19 1/2 n/a 24 Australia NCT04537351
COVID-19 2 BM 20 Pakistan NCT04444271
COVID-19 1/2 UC 75 United Kingdom NCT03042143
COVID-19 2 AT 100 USA NCT04362189
COVID-19 1/2 UC 30 Turkey NCT04392778
  1. Note: ALI/ARDS acute lung injury/acute respiratory distress syndrome, OA osteoarthritis, RA arthritis rheumatoid, CD Crohn’s diseases, SLE systemic lupus erythematosus, GvHD graft versus host disease, MS multiple sclerosis, COVID-19 coronavirus disease 2019, BM bone marrow, AT adipose tissue, UC umbilical cord, UCB umbilical cord blood, P placenta, WJ Wharton’s jelly, DP dental pulp, PB peripheral blood, n/a not available