From: Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders
Condition | Model | Main consequences | Ref |
---|---|---|---|
COPD | Ozone-induced mice | Protection against oxidative stress-induced mitochondrial dysfunction and decreasing airway inflammation after AT-MSC injection | [118] |
ALI/ARDS | Influenza virus-induced pig | Suppression of influenza virus replication and virus-elicited apoptosis in lung epithelial cells by MSC-extracellular vesicles (EVs) | [119] |
ALI/ARDS | LPS-induced mice | Reduced total protein and albumin concentrations in bronchoalveolar lavage fluid (BALF) along with attenuated levels of proinflammatory factors and amended rates of anti-inflammatory factors after BM-MSC injection | [120] |
ALI/ARDS | LPS-induced mice | Amelioration of lung function and reduction in alveolar collapse, tissue cellularity, collagen, and elastic fiber content in lung tissue in association with lessening in TNF-α, IL-1β, CXCL1, TGF-β, and VEGF by transplantation of MSCs derived from BM and AT | [121] |
ALI/ARDS | LPS-induced mice | Mitigated inflammation, oxidative damage, and reduced release of NETs, leading to the promoted overall survival rate of experimental models after MSC transplantation | [122] |
ALI/ARDS | LPS-induced mice | Protection against LPS-induced ALI/ARDS by reduction of serum amyloid A (SAA) levels following administration of exosomes derived from microRNA-30b-3p-overexpressing MSCs | [123] |
COPD | CS-induced rat | Reduction of TNF-α, IL-1β, MCP-1, and IL-6 and proteases MMP9 and MMP12 levels and promotion of VEGF, VEGF-R2, and TGF-β1 levels in lung tissue, and plummeting pulmonary cell apoptosis upon MSC transplantation | [124] |
Emphysema | Papain-induced rat | Induction of protection against pulmonary emphysema by increasing VEGF-A expression and preventing the apoptosis of lung cells after MSC injection | [125] |
PF | Silica-induced rat | Inflammatory response inhibition and reduced caspase-3 protein expression with a promotion in the Bcl-2/Bax ratio in pulmonary cell upon AT-MSC injection | [126] |
BPD | Hyperoxia-induced rat | Lung function rescue, inhibition of fibrosis and pulmonary vascular remodeling, and improvement of pulmonary hypertension upon MSC-Exo injection | [127] |
PF | Bleomycin-induced mice | Decrease of bleomycin-induced PF by AT-MSC intratracheal injection mediated by targeting miR-199 and caveolin-1 expression and AKT phosphorylation | [128] |
PF | Bleomycin-induced mice | Alleviation of PF and promotion of survival rate of experimental models after injection of hypoxia-preconditioned MSCs mediated by HGF upregulation | [129] |
ALI/ARDS | LPS-induced mice | Reduction in IL-1β and promotion of IL-10 levels in BALF as well as augmented expression of PCNA and KGF and diminished expression of caspase-3 following menstrual blood-derived stem cell (MenSC) injection | [130] |
Asthma | Ovalbumin-induced mice | Amelioration of the airway remodeling and inhibition of fibrosis by targeting TGF-β1/Smad pathway after systemic administration of human induced pluripotent stem cell (iPSC)-MSCs | [131] |
ALI/ARDS | Ventilator-induced rat | Reduction in albumin levels and inflammatory cells frequencies in BALF leading to the promoted overall survival of experimental models upon injection of UC-MSCs | [132] |
PF | Paraquat-induced mice | Inhibition of TNF-α, IL-1β, IL-6 and IL-10 generation resulted in PF restoration upon MSC administration | [133] |
PF | BLM-induced mice | PF amelioration upon inhibition of the IL6-IL10-TGF-β axis involving lung M2 macrophages after UC-MSC systemic injection | [134] |
Asthma | Ovalbumin-induced mice | Attenuation of numbers of goblet cells, the thicknesses of smooth muscle layer and collagen density along with inhibition of the expression of TGF-β1, TAK1, and p38MAPK in lung tissue after injection of erythropoietin (EPO) gene modified MSCs | [135] |
ALI/ARDS | Bleomycin-induced rat | Promotion of vascular permeability, decrease in the rates of proinflammatory cytokines, and improvement in anti-inflammatory cytokine IL-4 levels caused ALI/ARDS amelioration | [136] |
Asthma | Ovalbumin-induced mice | Mitigated IL-4, IL-13, and CCL11 levels and collagen fiber content and promoted IL-10 levels in BALF and improved lung function upon MSC administration | [137] |
Emphysema | CS-induced rat | Inhibition of induced emphysema development through differentiation of injected MSCs into type II alveolar epithelial cells and dwindled apoptosis and oxidative stress | [138] |
Asthma | Ovalbumin-induced mice | Restoration of asthmatic airway remodeling mediated by inhibition of TGF-β1 induced epithelial-mesenchymal transition upon hUC-MSC administration | [139] |
ALI/ARDS | LPS-induced rat | Inhibition of inflammatory response resulted in ALI/ARDS rescue after BM-MSC administration | [140] |
ALI/ARDS | Ventilator-induced rat | Decreased total lung water as well as dampened lung inflammation achieved by down regulation of TNF-α and up regulation of IL-10 after BM-MSC injection by intravenous route | [141] |
ALI/ARDS | Ventilator-induced pig | Absence of significant difference in lung injury rate in the presence of attenuation in expression levels of proinflammatory cytokine and NF-kB translocation upon UC-MSC administration | [142] |
ALI/ARDS | CS-induced sheep | Promoted oxygenation and reduced pulmonary edema following UC-MSC administration | [143] |