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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: The combination of G-CSF and AMD3100 mobilizes bone marrow-derived stem cells to protect against cisplatin-induced acute kidney injury in mice

Fig. 6

Effects of G-CSF/AMD3100 on renal tubular cell apoptosis. a–c Western blot analyses of BCL-2 and BAX protein. G-CSF/AMD3100 pretreatment showed a significant increase in BCL-2 expression but a decrease in BAX expression. d–g Representative micrographs showing the TUNEL immunostaining amongst different groups. d Cisplatin + saline-treated mice. e Cisplatin + G-CSF-pretreated mice. f Cisplatin + G-CSF/AMD3100-pretreated mice. g Quantitative analysis for the number of TUNEL staining-positive cells amongst different groups. Data represent the mean ± SD (n = 6 per group). *P < 0.05, **P < 0.01, ***P < 0.001. Original magnification × 400

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Stem Cell Research & Therapy

ISSN: 1757-6512